Usually, transplant patients take immunosuppressive drugs to prevent the transplanted organ from being rejected over the long term or to treat incipient rejection. They may start to take these drugs before surgery and continue throughout the life of the organ. Methylprednisolone and azathioprine are usually administered I.V. during surgery. As kidney function improves, the patient takes cyclosporine. Maintenance immunosuppressive therapy usually combines prednisone, azathioprine, and cyclosporine. Patients receiving tacrolimus have less risk of organ rejection and new-onset Type 1 diabetes.